ADAMTS13 Gene

What is the ADAMTS13 gene?

ADAMTS13 encodes adam metallopeptidase with thrombospondin type 1 motif 13, a protein involved in VWF processing. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. ADAMTS13 cleaves ultra-large VWF multimers released from endothelium into smaller, less adhesive forms. Deficiency causes thrombotic thrombocytopenic purpura (TTP) with widespread microvascular platelet thrombi.

Biological role and pathway

ADAMTS13 is involved in the VWF processing pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the ADAMTS13 gene have been studied in relation to coagulation and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs2285489— ADAMTS13 variant
• rs1048659— ADAMTS13 variant
• rs28933409— ADAMTS13 variant

Conditions studied in relation to ADAMTS13

Research into ADAMTS13 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that ADAMTS13 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ADAMTS13 and related genes in the coagulation & vascular pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Coagulation & Vascular pathway

ADAMTS13 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions