ADAMTS5 Gene

What is the ADAMTS5 gene?

ADAMTS5 encodes adam metallopeptidase with thrombospondin type 1 motif 5, a protein involved in aggrecanase / cartilage remodeling. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. ADAMTS5 is the primary aggrecanase that degrades aggrecan in cartilage, contributing to joint destruction.

Biological role and pathway

ADAMTS5 is involved in the aggrecanase / cartilage remodeling pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the ADAMTS5 gene have been studied in relation to connective tissue and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs229069— ADAMTS5 variant

Conditions studied in relation to ADAMTS5

Research into ADAMTS5 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that ADAMTS5 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ADAMTS5 and related genes in the coagulation & microcirculation pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Coagulation & Microcirculation pathway

ADAMTS5 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions