ALDOB Gene
Aldolase Fructose-Bisphosphate B (ALDOB) is a gene involved in fructose metabolism / glycolysis that has been studied in relation to immune function, metabolism, and chronic illness. Variants in ALDOB may influence how the body responds to infection, inflammation, and long-term recovery.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the ALDOB gene?
ALDOB encodes aldolase fructose-bisphosphate b, a protein involved in fructose metabolism / glycolysis. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. ALDOB encodes aldolase B, the liver fructose-metabolizing enzyme; deficiency causes hereditary fructose intolerance.
Biological role and pathway
ALDOB is involved in the fructose metabolism / glycolysis pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.
ALDOB and Long COVID / ME-CFS research
ALDOB variants affecting fructose metabolism may contribute to metabolic dysregulation; fructose metabolism in the gut and liver may be relevant to gut microbiome changes in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Known genetic variants
The following variants (SNPs) in the ALDOB gene have been studied in relation to metabolic and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.
- rs1048891— ALDOB variant
Conditions studied in relation to ALDOB
Research into ALDOB variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that ALDOB causes or treats any condition.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ALDOB and related genes in the metabolic regulation pathway.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the ALDOB gene and what does it do?
ALDOB (Aldolase Fructose-Bisphosphate B) is involved in fructose metabolism / glycolysis. ALDOB encodes aldolase B, the liver fructose-metabolizing enzyme; deficiency causes hereditary fructose intolerance.
How may ALDOB gene variants relate to Long COVID or ME/CFS?
ALDOB variants affecting fructose metabolism may contribute to metabolic dysregulation; fructose metabolism in the gut and liver may be relevant to gut microbiome changes in Long COVID.
Can a DNA test reveal information about my ALDOB gene?
Consumer DNA data from 23andMe, AncestryDNA, and MyHeritage includes SNP variants for many genes. ChronicDNA analyses your raw DNA file and reports on variants that have been studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Explore your ALDOB genetic insights
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ALDOB. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Human Genetics