CD47 Gene
CD47 Molecule (Integrin Associated Protein) (CD47) is a gene involved in don't eat me signal / phagocytosis regulation that has been studied in relation to immune function, metabolism, and chronic illness. Variants in CD47 may influence how the body responds to infection, inflammation, and long-term recovery.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the CD47 gene?
CD47 encodes cd47 molecule (integrin associated protein), a protein involved in don't eat me signal / phagocytosis regulation. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CD47 encodes integrin-associated protein, a 'don't eat me' signal on cells that engages SIRPα on macrophages to inhibit phagocytosis.
Biological role and pathway
CD47 is involved in the don't eat me signal / phagocytosis regulation pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.
CD47 and Long COVID / ME-CFS research
CD47 upregulation on infected cells inhibits phagocytic clearance; SARS-CoV-2-infected cells may exploit CD47 signaling to evade macrophage clearance, and CD47 variants may affect pathogen clearance in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Known genetic variants
The following variants (SNPs) in the CD47 gene have been studied in relation to immune signaling and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.
- rs8084— CD47 variant
Conditions studied in relation to CD47
Research into CD47 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that CD47 causes or treats any condition.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD47 and related genes in the immune system & inflammation pathway.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Related genes in the Immune System & Inflammation pathway
CD47 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.
Frequently asked questions
What is the CD47 gene and what does it do?
CD47 (CD47 Molecule (Integrin Associated Protein)) is involved in don't eat me signal / phagocytosis regulation. CD47 encodes integrin-associated protein, a 'don't eat me' signal on cells that engages SIRPα on macrophages to inhibit phagocytosis.
How may CD47 gene variants relate to Long COVID or ME/CFS?
CD47 upregulation on infected cells inhibits phagocytic clearance; SARS-CoV-2-infected cells may exploit CD47 signaling to evade macrophage clearance, and CD47 variants may affect pathogen clearance in Long COVID.
Can a DNA test reveal information about my CD47 gene?
Consumer DNA data from 23andMe, AncestryDNA, and MyHeritage includes SNP variants for many genes. ChronicDNA analyses your raw DNA file and reports on variants that have been studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Explore your CD47 genetic insights
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CD47. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Immunology
- [3]Cell