IL10RB Gene

What is the IL10RB gene?

IL10RB encodes interleukin 10 receptor subunit beta, a protein involved in IL-10 and type III IFN signaling. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL10RB encodes the shared beta chain of IL-10, IL-22, IL-26, and type III interferon receptors.

Biological role and pathway

IL10RB is involved in the IL-10 and type III IFN signaling pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the IL10RB gene have been studied in relation to immune signaling and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs2836443— IL10RB variant

Conditions studied in relation to IL10RB

Research into IL10RB variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that IL10RB causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL10RB and related genes in the cytokines & immune signaling pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Cytokines & Immune Signaling pathway

IL10RB does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions