LOXL2 Gene
Lysyl Oxidase Like 2 (LOXL2) is a gene involved in collagen crosslinking / fibrosis that has been studied in relation to immune function, metabolism, and chronic illness. Variants in LOXL2 may influence how the body responds to infection, inflammation, and long-term recovery.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the LOXL2 gene?
LOXL2 encodes lysyl oxidase like 2, a protein involved in collagen crosslinking / fibrosis. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. LOXL2 encodes a lysyl oxidase homolog involved in collagen fiber crosslinking and fibrosis regulation.
Biological role and pathway
LOXL2 is involved in the collagen crosslinking / fibrosis pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.
LOXL2 and Long COVID / ME-CFS research
LOXL2 promotes fibrotic remodeling by crosslinking collagen in fibrotic tissues; variants may affect post-COVID fibrotic complications in the lung and other tissues in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Known genetic variants
The following variants (SNPs) in the LOXL2 gene have been studied in relation to connective tissue and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.
- rs1898672— LOXL2 variant
Conditions studied in relation to LOXL2
Research into LOXL2 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that LOXL2 causes or treats any condition.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LOXL2 and related genes in the coagulation & microcirculation pathway.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Related genes in the Coagulation & Microcirculation pathway
LOXL2 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.
Frequently asked questions
What is the LOXL2 gene and what does it do?
LOXL2 (Lysyl Oxidase Like 2) is involved in collagen crosslinking / fibrosis. LOXL2 encodes a lysyl oxidase homolog involved in collagen fiber crosslinking and fibrosis regulation.
How may LOXL2 gene variants relate to Long COVID or ME/CFS?
LOXL2 promotes fibrotic remodeling by crosslinking collagen in fibrotic tissues; variants may affect post-COVID fibrotic complications in the lung and other tissues in Long COVID.
Can a DNA test reveal information about my LOXL2 gene?
Consumer DNA data from 23andMe, AncestryDNA, and MyHeritage includes SNP variants for many genes. ChronicDNA analyses your raw DNA file and reports on variants that have been studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Explore your LOXL2 genetic insights
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for LOXL2. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Nature Medicine