PTGS1 Gene
Prostaglandin-Endoperoxide Synthase 1 (PTGS1) is a gene involved in prostaglandin synthesis that has been studied in relation to immune function, metabolism, and chronic illness. Variants in PTGS1 may influence how the body responds to infection, inflammation, and long-term recovery.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the PTGS1 gene?
PTGS1 encodes prostaglandin-endoperoxide synthase 1, a protein involved in prostaglandin synthesis. It belongs to the Inflammation category and is part of the Immune System & Inflammation biological cluster. PTGS1 (COX-1) is the constitutively expressed cyclooxygenase that synthesizes prostaglandins for gastric protection, platelet TXA2 production, and homeostatic functions. It is irreversibly inhibited by aspirin.
Biological role and pathway
PTGS1 is involved in the prostaglandin synthesis pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.
PTGS1 and Long COVID / ME-CFS research
Aspirin's irreversible inhibition of COX-1 and platelet TXA2 synthesis is the basis for antiplatelet therapy in COVID-19-associated coagulopathy. PTGS1 variants affecting aspirin binding efficacy may influence aspirin antiplatelet response in Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Known genetic variants
The following variants (SNPs) in the PTGS1 gene have been studied in relation to inflammation and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.
- rs10306114— PTGS1 variant
- rs3842787— PTGS1 variant
- rs5789— PTGS1 variant
Conditions studied in relation to PTGS1
Research into PTGS1 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that PTGS1 causes or treats any condition.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PTGS1 and related genes in the immune system & inflammation pathway.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Related genes in the Immune System & Inflammation pathway
PTGS1 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.
Frequently asked questions
What is the PTGS1 gene and what does it do?
PTGS1 (Prostaglandin-Endoperoxide Synthase 1) is involved in prostaglandin synthesis. PTGS1 (COX-1) is the constitutively expressed cyclooxygenase that synthesizes prostaglandins for gastric protection, platelet TXA2 production, and homeostatic functions. It is irreversibly inhibited by aspirin.
How may PTGS1 gene variants relate to Long COVID or ME/CFS?
Aspirin's irreversible inhibition of COX-1 and platelet TXA2 synthesis is the basis for antiplatelet therapy in COVID-19-associated coagulopathy. PTGS1 variants affecting aspirin binding efficacy may influence aspirin antiplatelet response in Long COVID patients.
Can a DNA test reveal information about my PTGS1 gene?
Consumer DNA data from 23andMe, AncestryDNA, and MyHeritage includes SNP variants for many genes. ChronicDNA analyses your raw DNA file and reports on variants that have been studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Explore your PTGS1 genetic insights
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PTGS1. This is not an exhaustive literature review.
- [1]PMID: 28263999
- [2]Arteriosclerosis Thrombosis and Vascular Biology
- [3]Journal of Thrombosis and Haemostasis