SFTPC Gene

What is the SFTPC gene?

SFTPC encodes surfactant protein c, a protein involved in pulmonary surfactant production. It belongs to the Respiratory category and is part of the Respiratory & Lung Function biological cluster. SFTPC encodes surfactant protein C, essential for reducing alveolar surface tension and maintaining lung compliance.

Biological role and pathway

SFTPC is involved in the pulmonary surfactant production pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Respiratory & Lung Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the SFTPC gene have been studied in relation to respiratory and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs72928474— SFTPC variant

Conditions studied in relation to SFTPC

Research into SFTPC variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that SFTPC causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SFTPC and related genes in the respiratory & lung function pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Respiratory & Lung Function pathway

SFTPC does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions