rs1800977

What is the rs1800977 variant?

rs1800977 is a SNP (single nucleotide polymorphism) in the ABCA1 (ATP Binding Cassette Subfamily A Member 1) gene. It belongs to the Lipid Metabolism category and is part of the Lipid Metabolism biological cluster. ABCA1 encodes a transporter that exports cholesterol and phospholipids from cells to apoA-I, initiating HDL particle formation.

Biological role and pathway

This variant sits within the ABCA1 gene, which is involved in the cholesterol efflux and HDL formation pathway. Genes within the Lipid Metabolism cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: ABCA1

rs1800977 is one of 3 known variants in the ABCA1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1800977

Research into ABCA1 variants including rs1800977 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ABCA1 and the rs1800977 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the ABCA1 gene

The following variants in ABCA1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions