rs13333226
Variant in the ABCA3 gene (ATP Binding Cassette Subfamily A Member 3)
rs13333226 is a single nucleotide polymorphism (SNP) in the ABCA3 gene, involved in lamellar body formation / surfactant secretion. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs13333226 variant?
rs13333226 is a SNP (single nucleotide polymorphism) in the ABCA3 (ATP Binding Cassette Subfamily A Member 3) gene. It belongs to the Respiratory category and is part of the Respiratory & Lung Function biological cluster. ABCA3 encodes a lipid transporter essential for lamellar body formation and surfactant phospholipid secretion in alveolar type II cells.
Biological role and pathway
This variant sits within the ABCA3 gene, which is involved in the lamellar body formation / surfactant secretion pathway. Genes within the Respiratory & Lung Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs13333226 and Long COVID / ME-CFS research
ABCA3 mutations cause neonatal respiratory distress and ILD; variants may affect surfactant lipid composition and alveolar stability, influencing pulmonary recovery in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ABCA3
rs13333226 is one of 1 known variant in the ABCA3 gene. To understand the full biological context of this variant, explore the parent gene page.
View ABCA3 gene page →Conditions studied in relation to rs13333226
Research into ABCA3 variants including rs13333226 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ABCA3 and the rs13333226 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs13333226 variant in the ABCA3 gene?
rs13333226 is a single nucleotide polymorphism (SNP) located in the ABCA3 (ATP Binding Cassette Subfamily A Member 3) gene, which is involved in lamellar body formation / surfactant secretion. ABCA3 encodes a lipid transporter essential for lamellar body formation and surfactant phospholipid secretion in alveolar type II cells.
How may the rs13333226 variant relate to Long COVID or ME/CFS?
ABCA3 mutations cause neonatal respiratory distress and ILD; variants may affect surfactant lipid composition and alveolar stability, influencing pulmonary recovery in Long COVID.
Can a consumer DNA test detect the rs13333226 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs13333226 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ABCA3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]NEJM