rs2032582
Variant in the ABCB1 gene (ATP Binding Cassette Subfamily B Member 1 (P-glycoprotein))
rs2032582 is a single nucleotide polymorphism (SNP) in the ABCB1 gene, involved in drug efflux transport. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2032582 variant?
rs2032582 is a SNP (single nucleotide polymorphism) in the ABCB1 (ATP Binding Cassette Subfamily B Member 1 (P-glycoprotein)) gene. It belongs to the Drug Metabolism category and is part of the Detox & Medication Sensitivity biological cluster. ABCB1 encodes P-glycoprotein, the major drug efflux transporter in the gut, liver, kidney, and blood-brain barrier.
Biological role and pathway
This variant sits within the ABCB1 gene, which is involved in the drug efflux transport pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2032582 and Long COVID / ME-CFS research
ABCB1 variants affect drug absorption and CNS penetration of medications relevant to Long COVID management, including antivirals and antidepressants.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ABCB1
rs2032582 is one of 2 known variants in the ABCB1 gene. To understand the full biological context of this variant, explore the parent gene page.
View ABCB1 gene page →Conditions studied in relation to rs2032582
Research into ABCB1 variants including rs2032582 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ABCB1 and the rs2032582 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ABCB1 gene
The following variants in ABCB1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2032582 variant in the ABCB1 gene?
rs2032582 is a single nucleotide polymorphism (SNP) located in the ABCB1 (ATP Binding Cassette Subfamily B Member 1 (P-glycoprotein)) gene, which is involved in drug efflux transport. ABCB1 encodes P-glycoprotein, the major drug efflux transporter in the gut, liver, kidney, and blood-brain barrier.
How may the rs2032582 variant relate to Long COVID or ME/CFS?
ABCB1 variants affect drug absorption and CNS penetration of medications relevant to Long COVID management, including antivirals and antidepressants.
Can a consumer DNA test detect the rs2032582 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2032582 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ABCB1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26014458
- [2]Nature Genetics
- [3]Journal of Clinical Investigation