rs3815417
Variant in the ABCB11 gene (ATP Binding Cassette Subfamily B Member 11 (BSEP))
rs3815417 is a single nucleotide polymorphism (SNP) in the ABCB11 gene, involved in hepatocyte bile salt export. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3815417 variant?
rs3815417 is a SNP (single nucleotide polymorphism) in the ABCB11 (ATP Binding Cassette Subfamily B Member 11 (BSEP)) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. ABCB11 encodes the bile salt export pump (BSEP), the primary transporter for hepatocellular bile acid excretion into bile canaliculi.
Biological role and pathway
This variant sits within the ABCB11 gene, which is involved in the hepatocyte bile salt export pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3815417 and Long COVID / ME-CFS research
ABCB11 variants affect bile acid export; liver inflammation from COVID-19 may impair BSEP function, contributing to drug-induced liver injury or cholestatic disease relevant to Long COVID liver complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ABCB11
rs3815417 is one of 2 known variants in the ABCB11 gene. To understand the full biological context of this variant, explore the parent gene page.
View ABCB11 gene page →Conditions studied in relation to rs3815417
Research into ABCB11 variants including rs3815417 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ABCB11 and the rs3815417 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ABCB11 gene
The following variants in ABCB11 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3815417 variant in the ABCB11 gene?
rs3815417 is a single nucleotide polymorphism (SNP) located in the ABCB11 (ATP Binding Cassette Subfamily B Member 11 (BSEP)) gene, which is involved in hepatocyte bile salt export. ABCB11 encodes the bile salt export pump (BSEP), the primary transporter for hepatocellular bile acid excretion into bile canaliculi.
How may the rs3815417 variant relate to Long COVID or ME/CFS?
ABCB11 variants affect bile acid export; liver inflammation from COVID-19 may impair BSEP function, contributing to drug-induced liver injury or cholestatic disease relevant to Long COVID liver complications.
Can a consumer DNA test detect the rs3815417 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3815417 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ABCB11 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Hepatology