rs757110
Variant in the ABCC8 gene (ATP Binding Cassette Subfamily C Member 8 (SUR1))
rs757110 is a single nucleotide polymorphism (SNP) in the ABCC8 gene, involved in pancreatic ATP-sensitive potassium channel. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs757110 variant?
rs757110 is a SNP (single nucleotide polymorphism) in the ABCC8 (ATP Binding Cassette Subfamily C Member 8 (SUR1)) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. ABCC8 encodes SUR1, the regulatory subunit of the pancreatic beta cell ATP-sensitive K+ channel that regulates insulin secretion.
Biological role and pathway
This variant sits within the ABCC8 gene, which is involved in the pancreatic ATP-sensitive potassium channel pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs757110 and Long COVID / ME-CFS research
ABCC8 variants affect insulin secretion dynamics; post-COVID beta cell dysfunction and new-onset diabetes may be influenced by ABCC8 variants affecting beta cell electrophysiology.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ABCC8
rs757110 is one of 2 known variants in the ABCC8 gene. To understand the full biological context of this variant, explore the parent gene page.
View ABCC8 gene page →Conditions studied in relation to rs757110
Research into ABCC8 variants including rs757110 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ABCC8 and the rs757110 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ABCC8 gene
The following variants in ABCC8 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs757110 variant in the ABCC8 gene?
rs757110 is a single nucleotide polymorphism (SNP) located in the ABCC8 (ATP Binding Cassette Subfamily C Member 8 (SUR1)) gene, which is involved in pancreatic ATP-sensitive potassium channel. ABCC8 encodes SUR1, the regulatory subunit of the pancreatic beta cell ATP-sensitive K+ channel that regulates insulin secretion.
How may the rs757110 variant relate to Long COVID or ME/CFS?
ABCC8 variants affect insulin secretion dynamics; post-COVID beta cell dysfunction and new-onset diabetes may be influenced by ABCC8 variants affecting beta cell electrophysiology.
Can a consumer DNA test detect the rs757110 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs757110 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ABCC8 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]NEJM