rs2231137
Variant in the ABCG2 gene (ATP Binding Cassette Subfamily G Member 2)
rs2231137 is a single nucleotide polymorphism (SNP) in the ABCG2 gene, involved in drug transport. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2231137 variant?
rs2231137 is a SNP (single nucleotide polymorphism) in the ABCG2 (ATP Binding Cassette Subfamily G Member 2) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. ABCG2 (BCRP) is a broad-specificity efflux transporter in intestine, liver, and blood-brain barrier that limits absorption and CNS penetration of diverse drugs. It also transports uric acid and its variants cause gout.
Biological role and pathway
This variant sits within the ABCG2 gene, which is involved in the drug transport pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2231137 and Long COVID / ME-CFS research
ABCG2 rs2231142 (Q141K) reduces uric acid excretion (gout risk) and affects drug bioavailability. Uric acid is elevated in COVID-19, and ABCG2 variants may influence both COVID-related hyperuricemia and the pharmacokinetics of antivirals used for SARS-CoV-2.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ABCG2
rs2231137 is one of 3 known variants in the ABCG2 gene. To understand the full biological context of this variant, explore the parent gene page.
View ABCG2 gene page →Conditions studied in relation to rs2231137
Research into ABCG2 variants including rs2231137 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ABCG2 and the rs2231137 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ABCG2 gene
The following variants in ABCG2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2231137 variant in the ABCG2 gene?
rs2231137 is a single nucleotide polymorphism (SNP) located in the ABCG2 (ATP Binding Cassette Subfamily G Member 2) gene, which is involved in drug transport. ABCG2 (BCRP) is a broad-specificity efflux transporter in intestine, liver, and blood-brain barrier that limits absorption and CNS penetration of diverse drugs. It also transports uric acid and its variants cause gout.
How may the rs2231137 variant relate to Long COVID or ME/CFS?
ABCG2 rs2231142 (Q141K) reduces uric acid excretion (gout risk) and affects drug bioavailability. Uric acid is elevated in COVID-19, and ABCG2 variants may influence both COVID-related hyperuricemia and the pharmacokinetics of antivirals used for SARS-CoV-2.
Can a consumer DNA test detect the rs2231137 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2231137 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ABCG2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 27402600
- [2]Nature Genetics
- [3]Clinical Pharmacology & Therapeutics