rs657152
Variant in the ABO gene (ABO Blood Group)
rs657152 is a single nucleotide polymorphism (SNP) in the ABO gene, involved in glycosylation and blood group antigens. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs657152 variant?
rs657152 is a SNP (single nucleotide polymorphism) in the ABO (ABO Blood Group) gene. It belongs to the Immune Regulation category and is part of the Immune Regulation biological cluster. ABO encodes glycosyltransferases defining ABO blood group antigens, which influence complement activity, inflammation, and SARS-CoV-2 susceptibility.
Biological role and pathway
This variant sits within the ABO gene, which is involved in the glycosylation and blood group antigens pathway. Genes within the Immune Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs657152 and Long COVID / ME-CFS research
ABO blood group has been associated with COVID-19 susceptibility; type O blood may be associated with lower SARS-CoV-2 binding and different Long COVID risk.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ABO
rs657152 is one of 2 known variants in the ABO gene. To understand the full biological context of this variant, explore the parent gene page.
View ABO gene page →Conditions studied in relation to rs657152
Research into ABO variants including rs657152 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ABO and the rs657152 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ABO gene
The following variants in ABO are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs657152 variant in the ABO gene?
rs657152 is a single nucleotide polymorphism (SNP) located in the ABO (ABO Blood Group) gene, which is involved in glycosylation and blood group antigens. ABO encodes glycosyltransferases defining ABO blood group antigens, which influence complement activity, inflammation, and SARS-CoV-2 susceptibility.
How may the rs657152 variant relate to Long COVID or ME/CFS?
ABO blood group has been associated with COVID-19 susceptibility; type O blood may be associated with lower SARS-CoV-2 binding and different Long COVID risk.
Can a consumer DNA test detect the rs657152 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs657152 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ABO and its variants. This is not an exhaustive literature review.
- [1]PMID: 33888513
- [2]Nature Genetics
- [3]Journal of Clinical Investigation