rs1799958
Variant in the ACADM gene (Acyl-CoA Dehydrogenase Medium Chain)
rs1799958 is a single nucleotide polymorphism (SNP) in the ACADM gene, involved in medium-chain fatty acid beta-oxidation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1799958 variant?
rs1799958 is a SNP (single nucleotide polymorphism) in the ACADM (Acyl-CoA Dehydrogenase Medium Chain) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. ACADM encodes medium-chain acyl-CoA dehydrogenase (MCAD), the enzyme for medium-chain fatty acid beta-oxidation in mitochondria.
Biological role and pathway
This variant sits within the ACADM gene, which is involved in the medium-chain fatty acid beta-oxidation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1799958 and Long COVID / ME-CFS research
ACADM variants affect fatty acid oxidation capacity; impaired mitochondrial energy production may contribute to fatigue and exercise intolerance in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ACADM
rs1799958 is one of 2 known variants in the ACADM gene. To understand the full biological context of this variant, explore the parent gene page.
View ACADM gene page →Conditions studied in relation to rs1799958
Research into ACADM variants including rs1799958 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ACADM and the rs1799958 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ACADM gene
The following variants in ACADM are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1799958 variant in the ACADM gene?
rs1799958 is a single nucleotide polymorphism (SNP) located in the ACADM (Acyl-CoA Dehydrogenase Medium Chain) gene, which is involved in medium-chain fatty acid beta-oxidation. ACADM encodes medium-chain acyl-CoA dehydrogenase (MCAD), the enzyme for medium-chain fatty acid beta-oxidation in mitochondria.
How may the rs1799958 variant relate to Long COVID or ME/CFS?
ACADM variants affect fatty acid oxidation capacity; impaired mitochondrial energy production may contribute to fatigue and exercise intolerance in Long COVID.
Can a consumer DNA test detect the rs1799958 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1799958 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ACADM and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Human Molecular Genetics