rs2285666
Variant in the ACE2 gene (Angiotensin-Converting Enzyme 2)
rs2285666 is a single nucleotide polymorphism (SNP) in the ACE2 gene, involved in renin-angiotensin system and viral entry. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2285666 variant?
rs2285666 is a SNP (single nucleotide polymorphism) in the ACE2 (Angiotensin-Converting Enzyme 2) gene. It belongs to the Viral Entry category and is part of the Viral Entry & Receptors biological cluster. ACE2 encodes the primary entry receptor for SARS-CoV-2 and is a key regulator of the renin-angiotensin system in the cardiovascular and pulmonary systems.
Biological role and pathway
This variant sits within the ACE2 gene, which is involved in the renin-angiotensin system and viral entry pathway. Genes within the Viral Entry & Receptors cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2285666 and Long COVID / ME-CFS research
ACE2 downregulation following SARS-CoV-2 infection may contribute to angiotensin II excess, vascular dysfunction, and lung injury in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ACE2
rs2285666 is one of 2 known variants in the ACE2 gene. To understand the full biological context of this variant, explore the parent gene page.
View ACE2 gene page →Conditions studied in relation to rs2285666
Research into ACE2 variants including rs2285666 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ACE2 and the rs2285666 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ACE2 gene
The following variants in ACE2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2285666 variant in the ACE2 gene?
rs2285666 is a single nucleotide polymorphism (SNP) located in the ACE2 (Angiotensin-Converting Enzyme 2) gene, which is involved in renin-angiotensin system and viral entry. ACE2 encodes the primary entry receptor for SARS-CoV-2 and is a key regulator of the renin-angiotensin system in the cardiovascular and pulmonary systems.
How may the rs2285666 variant relate to Long COVID or ME/CFS?
ACE2 downregulation following SARS-CoV-2 infection may contribute to angiotensin II excess, vascular dysfunction, and lung injury in Long COVID.
Can a consumer DNA test detect the rs2285666 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Related articles
- Long COVID Genetic Testing: What Your DNA Can Show
Can long COVID genetic testing help? Learn what consumer DNA tests can and cannot reveal, and how raw data links to viral entry and interferon genes.
- Long COVID Genetics: What Host DNA Research Suggests
A plain-English guide to long COVID genetics: how genes for viral entry, interferon signaling and immune clearance may shape risk and recovery.
- Why Does Long COVID Happen? Causes and Genetics
Why does Long COVID happen? Explore leading theories, from viral persistence to microclots, and how genes like ACE2 and IFNL3 may play a role.
Find out if you carry the rs2285666 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ACE2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32142651
- [2]Nature Genetics
- [3]Journal of Clinical Investigation