rs2070600

What is the rs2070600 variant?

rs2070600 is a SNP (single nucleotide polymorphism) in the ACTA2 (Actin Alpha 2 Smooth Muscle) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. ACTA2 encodes smooth muscle alpha-actin, the major contractile protein in vascular smooth muscle cells.

Biological role and pathway

This variant sits within the ACTA2 gene, which is involved in the smooth muscle contraction / vascular integrity pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: ACTA2

rs2070600 is one of 1 known variant in the ACTA2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2070600

Research into ACTA2 variants including rs2070600 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ACTA2 and the rs2070600 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions