rs1229984
Variant in the ADH1B gene (Alcohol Dehydrogenase 1B)
rs1229984 is a single nucleotide polymorphism (SNP) in the ADH1B gene, involved in alcohol and retinol metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1229984 variant?
rs1229984 is a SNP (single nucleotide polymorphism) in the ADH1B (Alcohol Dehydrogenase 1B) gene. It belongs to the Drug Metabolism category and is part of the Detox & Medication Sensitivity biological cluster. ADH1B encodes alcohol dehydrogenase 1B, which converts ethanol to acetaldehyde and also metabolizes vitamin A.
Biological role and pathway
This variant sits within the ADH1B gene, which is involved in the alcohol and retinol metabolism pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1229984 and Long COVID / ME-CFS research
ADH1B variants may influence aldehyde accumulation and oxidative stress relevant to mitochondrial and cellular dysfunction in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ADH1B
rs1229984 is one of 2 known variants in the ADH1B gene. To understand the full biological context of this variant, explore the parent gene page.
View ADH1B gene page →Conditions studied in relation to rs1229984
Research into ADH1B variants including rs1229984 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ADH1B and the rs1229984 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ADH1B gene
The following variants in ADH1B are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1229984 variant in the ADH1B gene?
rs1229984 is a single nucleotide polymorphism (SNP) located in the ADH1B (Alcohol Dehydrogenase 1B) gene, which is involved in alcohol and retinol metabolism. ADH1B encodes alcohol dehydrogenase 1B, which converts ethanol to acetaldehyde and also metabolizes vitamin A.
How may the rs1229984 variant relate to Long COVID or ME/CFS?
ADH1B variants may influence aldehyde accumulation and oxidative stress relevant to mitochondrial and cellular dysfunction in Long COVID.
Can a consumer DNA test detect the rs1229984 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1229984 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ADH1B and its variants. This is not an exhaustive literature review.
- [1]PMID: 26014458
- [2]Nature Genetics
- [3]Journal of Clinical Investigation