rs1048101

What is the rs1048101 variant?

rs1048101 is a SNP (single nucleotide polymorphism) in the ADRA1A (Adrenoceptor Alpha 1A) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. ADRA1A encodes the alpha-1A adrenergic receptor, which mediates vasoconstriction and smooth muscle contraction.

Biological role and pathway

This variant sits within the ADRA1A gene, which is involved in the adrenergic receptor signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: ADRA1A

rs1048101 is one of 1 known variant in the ADRA1A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1048101

Research into ADRA1A variants including rs1048101 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ADRA1A and the rs1048101 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the ADRA1A gene

The following variants in ADRA1A are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions

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