rs1801253
Variant in the ADRB1 gene (Adrenoceptor Beta 1)
rs1801253 is a single nucleotide polymorphism (SNP) in the ADRB1 gene, involved in cardiac sympathetic signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1801253 variant?
rs1801253 is a SNP (single nucleotide polymorphism) in the ADRB1 (Adrenoceptor Beta 1) gene. It belongs to the Cardiovascular category and is part of the Autonomic Nervous System biological cluster. ADRB1 encodes the cardiac beta-1 adrenergic receptor, which mediates sympathetic stimulation of heart rate and contractility.
Biological role and pathway
This variant sits within the ADRB1 gene, which is involved in the cardiac sympathetic signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1801253 and Long COVID / ME-CFS research
Beta-1 adrenergic signaling drives heart rate response to sympathetic activation; ADRB1 Arg389Gly and Ser49Gly variants affect cardiac receptor sensitivity and may influence tachycardia in Long COVID POTS.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ADRB1
rs1801253 is one of 2 known variants in the ADRB1 gene. To understand the full biological context of this variant, explore the parent gene page.
View ADRB1 gene page →Conditions studied in relation to rs1801253
Research into ADRB1 variants including rs1801253 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ADRB1 and the rs1801253 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ADRB1 gene
The following variants in ADRB1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1801253 variant in the ADRB1 gene?
rs1801253 is a single nucleotide polymorphism (SNP) located in the ADRB1 (Adrenoceptor Beta 1) gene, which is involved in cardiac sympathetic signaling. ADRB1 encodes the cardiac beta-1 adrenergic receptor, which mediates sympathetic stimulation of heart rate and contractility.
How may the rs1801253 variant relate to Long COVID or ME/CFS?
Beta-1 adrenergic signaling drives heart rate response to sympathetic activation; ADRB1 Arg389Gly and Ser49Gly variants affect cardiac receptor sensitivity and may influence tachycardia in Long COVID POTS.
Can a consumer DNA test detect the rs1801253 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1801253 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ADRB1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Circulation