rs5186
Variant in the AGTR1 gene (Angiotensin II Receptor Type 1)
rs5186 is a single nucleotide polymorphism (SNP) in the AGTR1 gene, involved in renin-angiotensin system. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs5186 variant?
rs5186 is a SNP (single nucleotide polymorphism) in the AGTR1 (Angiotensin II Receptor Type 1) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. AGTR1 encodes the angiotensin II receptor type 1, the primary mediator of angiotensin II's vasoconstrictive and pro-inflammatory effects.
Biological role and pathway
This variant sits within the AGTR1 gene, which is involved in the renin-angiotensin system pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs5186 and Long COVID / ME-CFS research
AGTR1 signaling is amplified when ACE2 is downregulated after SARS-CoV-2 infection, contributing to hypertension and vascular inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: AGTR1
rs5186 is one of 2 known variants in the AGTR1 gene. To understand the full biological context of this variant, explore the parent gene page.
View AGTR1 gene page →Conditions studied in relation to rs5186
Research into AGTR1 variants including rs5186 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AGTR1 and the rs5186 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the AGTR1 gene
The following variants in AGTR1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs5186 variant in the AGTR1 gene?
rs5186 is a single nucleotide polymorphism (SNP) located in the AGTR1 (Angiotensin II Receptor Type 1) gene, which is involved in renin-angiotensin system. AGTR1 encodes the angiotensin II receptor type 1, the primary mediator of angiotensin II's vasoconstrictive and pro-inflammatory effects.
How may the rs5186 variant relate to Long COVID or ME/CFS?
AGTR1 signaling is amplified when ACE2 is downregulated after SARS-CoV-2 infection, contributing to hypertension and vascular inflammation in Long COVID.
Can a consumer DNA test detect the rs5186 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs5186 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for AGTR1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32734001
- [2]Nature Genetics
- [3]Journal of Clinical Investigation