rs1403543

What is the rs1403543 variant?

rs1403543 is a SNP (single nucleotide polymorphism) in the AGTR2 (Angiotensin II Receptor Type 2) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. AGTR2 encodes angiotensin II receptor type 2, which counteracts AGTR1 effects and has vasodilatory and anti-inflammatory functions.

Biological role and pathway

This variant sits within the AGTR2 gene, which is involved in the renin-angiotensin protective signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: AGTR2

rs1403543 is one of 1 known variant in the AGTR2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1403543

Research into AGTR2 variants including rs1403543 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AGTR2 and the rs1403543 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions