rs2276415

What is the rs2276415 variant?

rs2276415 is a SNP (single nucleotide polymorphism) in the AIM2 (Absent In Melanoma 2) gene. It belongs to the Immune Signaling category and is part of the Viral Defense & Interferon Response biological cluster. AIM2 encodes an innate immune sensor that detects cytosolic double-stranded DNA and forms an inflammasome to activate caspase-1.

Biological role and pathway

This variant sits within the AIM2 gene, which is involved in the cytosolic DNA sensing / inflammasome pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: AIM2

rs2276415 is one of 1 known variant in the AIM2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2276415

Research into AIM2 variants including rs2276415 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AIM2 and the rs2276415 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the AIM2 gene

The following variants in AIM2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions