rs671

What is the rs671 variant?

rs671 is a SNP (single nucleotide polymorphism) in the ALDH2 (Aldehyde Dehydrogenase 2) gene. It belongs to the Drug Metabolism category and is part of the Detox & Medication Sensitivity biological cluster. ALDH2 encodes mitochondrial aldehyde dehydrogenase 2, critical for detoxifying acetaldehyde and other aldehydes.

Biological role and pathway

This variant sits within the ALDH2 gene, which is involved in the aldehyde detoxification pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: ALDH2

rs671 is one of 1 known variant in the ALDH2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs671

Research into ALDH2 variants including rs671 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ALDH2 and the rs671 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions