rs434473
Variant in the ALOX12 gene (Arachidonate 12-Lipoxygenase)
rs434473 is a single nucleotide polymorphism (SNP) in the ALOX12 gene, involved in 12-HETE platelet and immune cell signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs434473 variant?
rs434473 is a SNP (single nucleotide polymorphism) in the ALOX12 (Arachidonate 12-Lipoxygenase) gene. It belongs to the Immune Signaling category and is part of the Histamine & MCAS biological cluster. ALOX12 encodes 12-lipoxygenase, which converts arachidonic acid to 12-HETE, a lipid mediator affecting platelet function and pain signaling.
Biological role and pathway
This variant sits within the ALOX12 gene, which is involved in the 12-HETE platelet and immune cell signaling pathway. Genes within the Histamine & MCAS cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs434473 and Long COVID / ME-CFS research
12-HETE produced by ALOX12 activates platelets and potentiates pain signaling; variants may affect platelet hyperreactivity and pain sensitization in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ALOX12
rs434473 is one of 2 known variants in the ALOX12 gene. To understand the full biological context of this variant, explore the parent gene page.
View ALOX12 gene page →Conditions studied in relation to rs434473
Research into ALOX12 variants including rs434473 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ALOX12 and the rs434473 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ALOX12 gene
The following variants in ALOX12 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs434473 variant in the ALOX12 gene?
rs434473 is a single nucleotide polymorphism (SNP) located in the ALOX12 (Arachidonate 12-Lipoxygenase) gene, which is involved in 12-HETE platelet and immune cell signaling. ALOX12 encodes 12-lipoxygenase, which converts arachidonic acid to 12-HETE, a lipid mediator affecting platelet function and pain signaling.
How may the rs434473 variant relate to Long COVID or ME/CFS?
12-HETE produced by ALOX12 activates platelets and potentiates pain signaling; variants may affect platelet hyperreactivity and pain sensitization in Long COVID.
Can a consumer DNA test detect the rs434473 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs434473 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ALOX12 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33398161
- [2]Nature Genetics
- [3]Arteriosclerosis Thrombosis and Vascular Biology