rs154268

What is the rs154268 variant?

rs154268 is a SNP (single nucleotide polymorphism) in the PRKAA1 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. PRKAA1 encodes the alpha1 catalytic subunit of AMP-activated protein kinase (AMPK), a central energy sensor activated by ATP depletion.

Biological role and pathway

This variant sits within the PRKAA1 gene, which is involved in the AMPK energy sensing / mitochondrial regulation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PRKAA1

rs154268 is one of 1 known variant in the PRKAA1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs154268

Research into PRKAA1 variants including rs154268 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PRKAA1 and the rs154268 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions