rs1049742
Variant in the AOC1 gene (Amine Oxidase Copper Containing 1)
rs1049742 is a single nucleotide polymorphism (SNP) in the AOC1 gene, involved in histamine metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1049742 variant?
rs1049742 is a SNP (single nucleotide polymorphism) in the AOC1 (Amine Oxidase Copper Containing 1) gene. It belongs to the Metabolism category and is part of the Adaptive Immunity biological cluster. AOC1 (DAO) is the extracellular enzyme that oxidizes histamine from dietary sources in the gut epithelium, providing the primary defense against food-derived histamine. Variants reduce DAO activity, causing dietary histamine intolerance.
Biological role and pathway
This variant sits within the AOC1 gene, which is involved in the histamine metabolism pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1049742 and Long COVID / ME-CFS research
Reduced DAO activity is a well-recognized cause of dietary histamine intolerance with symptoms identical to mast cell activation. In Long COVID, impaired AOC1 function combined with gut dysbiosis and elevated endogenous histamine may exacerbate histamine-driven symptoms.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: AOC1
rs1049742 is one of 3 known variants in the AOC1 gene. To understand the full biological context of this variant, explore the parent gene page.
View AOC1 gene page →Conditions studied in relation to rs1049742
Research into AOC1 variants including rs1049742 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AOC1 and the rs1049742 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the AOC1 gene
The following variants in AOC1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1049742 variant in the AOC1 gene?
rs1049742 is a single nucleotide polymorphism (SNP) located in the AOC1 (Amine Oxidase Copper Containing 1) gene, which is involved in histamine metabolism. AOC1 (DAO) is the extracellular enzyme that oxidizes histamine from dietary sources in the gut epithelium, providing the primary defense against food-derived histamine. Variants reduce DAO activity, causing dietary histamine intolerance.
How may the rs1049742 variant relate to Long COVID or ME/CFS?
Reduced DAO activity is a well-recognized cause of dietary histamine intolerance with symptoms identical to mast cell activation. In Long COVID, impaired AOC1 function combined with gut dysbiosis and elevated endogenous histamine may exacerbate histamine-driven symptoms.
Can a consumer DNA test detect the rs1049742 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Related articles
- Long COVID MCAS: Mast Cells, Histamine and Your Genes
Learn how Long COVID MCAS may develop, how it overlaps with POTS and histamine intolerance, and which genes research links to mast cell activity.
Find out if you carry the rs1049742 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for AOC1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29071279
- [2]Journal of Allergy and Clinical Immunology
- [3]Inflammation Research