rs4647905
Variant in the JUN gene (Jun Proto-Oncogene AP-1 Transcription Factor Subunit)
rs4647905 is a single nucleotide polymorphism (SNP) in the JUN gene, involved in AP-1 transcription / stress response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4647905 variant?
rs4647905 is a SNP (single nucleotide polymorphism) in the JUN (Jun Proto-Oncogene AP-1 Transcription Factor Subunit) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. JUN encodes the c-Jun component of AP-1 transcription factors, activated by stress kinases (JNK, MAPK) to drive inflammatory gene expression.
Biological role and pathway
This variant sits within the JUN gene, which is involved in the AP-1 transcription / stress response pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4647905 and Long COVID / ME-CFS research
AP-1/JUN drives inflammatory gene expression in response to cytokines and stress signals; variants may affect the magnitude of MAPK-AP-1 driven inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: JUN
rs4647905 is one of 1 known variant in the JUN gene. To understand the full biological context of this variant, explore the parent gene page.
View JUN gene page →Conditions studied in relation to rs4647905
Research into JUN variants including rs4647905 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include JUN and the rs4647905 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs4647905 variant in the JUN gene?
rs4647905 is a single nucleotide polymorphism (SNP) located in the JUN (Jun Proto-Oncogene AP-1 Transcription Factor Subunit) gene, which is involved in AP-1 transcription / stress response. JUN encodes the c-Jun component of AP-1 transcription factors, activated by stress kinases (JNK, MAPK) to drive inflammatory gene expression.
How may the rs4647905 variant relate to Long COVID or ME/CFS?
AP-1/JUN drives inflammatory gene expression in response to cytokines and stress signals; variants may affect the magnitude of MAPK-AP-1 driven inflammation in Long COVID.
Can a consumer DNA test detect the rs4647905 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4647905 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for JUN and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Cell