rs670
Variant in the APOA1 gene (Apolipoprotein A1)
rs670 is a single nucleotide polymorphism (SNP) in the APOA1 gene, involved in HDL metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs670 variant?
rs670 is a SNP (single nucleotide polymorphism) in the APOA1 (Apolipoprotein A1) gene. It belongs to the Metabolism category and is part of the Mitochondrial & Metabolic biological cluster. ApoA-I is the major structural protein of HDL particles and activates LCAT for cholesterol esterification. It mediates reverse cholesterol transport and has anti-inflammatory and antioxidant functions.
Biological role and pathway
This variant sits within the APOA1 gene, which is involved in the HDL metabolism pathway. Genes within the Mitochondrial & Metabolic cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs670 and Long COVID / ME-CFS research
ApoA-I and HDL are reduced in COVID-19 severity and may mediate anti-inflammatory effects. HDL-bound ApoA-I limits LPS binding to TLR4; reduced APOA1 from APOA1 cluster variants may impair innate immune regulation relevant to Long COVID endotoxemia and inflammation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: APOA1
rs670 is one of 3 known variants in the APOA1 gene. To understand the full biological context of this variant, explore the parent gene page.
View APOA1 gene page →Conditions studied in relation to rs670
Research into APOA1 variants including rs670 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include APOA1 and the rs670 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the APOA1 gene
The following variants in APOA1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs670 variant in the APOA1 gene?
rs670 is a single nucleotide polymorphism (SNP) located in the APOA1 (Apolipoprotein A1) gene, which is involved in HDL metabolism. ApoA-I is the major structural protein of HDL particles and activates LCAT for cholesterol esterification. It mediates reverse cholesterol transport and has anti-inflammatory and antioxidant functions.
How may the rs670 variant relate to Long COVID or ME/CFS?
ApoA-I and HDL are reduced in COVID-19 severity and may mediate anti-inflammatory effects. HDL-bound ApoA-I limits LPS binding to TLR4; reduced APOA1 from APOA1 cluster variants may impair innate immune regulation relevant to Long COVID endotoxemia and inflammation.
Can a consumer DNA test detect the rs670 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs670 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for APOA1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 31263276
- [2]Nature Genetics
- [3]Cell Metabolism