rs3135506
Variant in the APOA5 gene (Apolipoprotein A5)
rs3135506 is a single nucleotide polymorphism (SNP) in the APOA5 gene, involved in triglyceride metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3135506 variant?
rs3135506 is a SNP (single nucleotide polymorphism) in the APOA5 (Apolipoprotein A5) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. APOA5 encodes apolipoprotein A-V, which reduces plasma triglyceride levels by activating lipoprotein lipase.
Biological role and pathway
This variant sits within the APOA5 gene, which is involved in the triglyceride metabolism pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3135506 and Long COVID / ME-CFS research
APOA5 variants are major determinants of plasma triglyceride levels; hypertriglyceridemia in Long COVID may be influenced by APOA5 variants.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: APOA5
rs3135506 is one of 2 known variants in the APOA5 gene. To understand the full biological context of this variant, explore the parent gene page.
View APOA5 gene page →Conditions studied in relation to rs3135506
Research into APOA5 variants including rs3135506 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include APOA5 and the rs3135506 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the APOA5 gene
The following variants in APOA5 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3135506 variant in the APOA5 gene?
rs3135506 is a single nucleotide polymorphism (SNP) located in the APOA5 (Apolipoprotein A5) gene, which is involved in triglyceride metabolism. APOA5 encodes apolipoprotein A-V, which reduces plasma triglyceride levels by activating lipoprotein lipase.
How may the rs3135506 variant relate to Long COVID or ME/CFS?
APOA5 variants are major determinants of plasma triglyceride levels; hypertriglyceridemia in Long COVID may be influenced by APOA5 variants.
Can a consumer DNA test detect the rs3135506 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3135506 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for APOA5 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]NEJM