rs512535
Variant in the APOB gene (Apolipoprotein B)
rs512535 is a single nucleotide polymorphism (SNP) in the APOB gene, involved in lipid transport. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs512535 variant?
rs512535 is a SNP (single nucleotide polymorphism) in the APOB (Apolipoprotein B) gene. It belongs to the Metabolism category and is part of the Mitochondrial & Metabolic biological cluster. ApoB is the structural protein of LDL, VLDL, and IDL particles and the sole apoprotein of LDL. APOB variants affect LDL levels and cardiovascular disease risk. Familial defective ApoB causes elevated LDL.
Biological role and pathway
This variant sits within the APOB gene, which is involved in the lipid transport pathway. Genes within the Mitochondrial & Metabolic cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs512535 and Long COVID / ME-CFS research
Lipid dysregulation is documented in COVID-19 and Long COVID, with altered HDL/LDL profiles. Elevated LDL contributes to COVID-19-related cardiovascular complications and accelerated atherosclerosis. APOB variants affecting LDL particle levels may influence Long COVID cardiovascular risk.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: APOB
rs512535 is one of 3 known variants in the APOB gene. To understand the full biological context of this variant, explore the parent gene page.
View APOB gene page →Conditions studied in relation to rs512535
Research into APOB variants including rs512535 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include APOB and the rs512535 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the APOB gene
The following variants in APOB are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs512535 variant in the APOB gene?
rs512535 is a single nucleotide polymorphism (SNP) located in the APOB (Apolipoprotein B) gene, which is involved in lipid transport. ApoB is the structural protein of LDL, VLDL, and IDL particles and the sole apoprotein of LDL. APOB variants affect LDL levels and cardiovascular disease risk. Familial defective ApoB causes elevated LDL.
How may the rs512535 variant relate to Long COVID or ME/CFS?
Lipid dysregulation is documented in COVID-19 and Long COVID, with altered HDL/LDL profiles. Elevated LDL contributes to COVID-19-related cardiovascular complications and accelerated atherosclerosis. APOB variants affecting LDL particle levels may influence Long COVID cardiovascular risk.
Can a consumer DNA test detect the rs512535 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs512535 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for APOB and its variants. This is not an exhaustive literature review.
- [1]PMID: 29343730
- [2]Nature Genetics
- [3]Cell