rs8177832
Variant in the APOBEC3G gene (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3G)
rs8177832 is a single nucleotide polymorphism (SNP) in the APOBEC3G gene, involved in antiviral restriction. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs8177832 variant?
rs8177832 is a SNP (single nucleotide polymorphism) in the APOBEC3G (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3G) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. APOBEC3G is a cytidine deaminase that restricts retroviruses and other DNA-based parasites by deaminating cytosines in single-stranded DNA during reverse transcription. It is part of the intrinsic antiviral restriction factor family.
Biological role and pathway
This variant sits within the APOBEC3G gene, which is involved in the antiviral restriction pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs8177832 and Long COVID / ME-CFS research
APOBEC3G restricts viral DNA intermediates and shapes the mutational landscape of viruses. Its role in broader antiviral innate immunity may affect susceptibility to SARS-CoV-2 sequelae through modulation of viral diversity and clearance.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: APOBEC3G
rs8177832 is one of 2 known variants in the APOBEC3G gene. To understand the full biological context of this variant, explore the parent gene page.
View APOBEC3G gene page →Conditions studied in relation to rs8177832
Research into APOBEC3G variants including rs8177832 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include APOBEC3G and the rs8177832 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the APOBEC3G gene
The following variants in APOBEC3G are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs8177832 variant in the APOBEC3G gene?
rs8177832 is a single nucleotide polymorphism (SNP) located in the APOBEC3G (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3G) gene, which is involved in antiviral restriction. APOBEC3G is a cytidine deaminase that restricts retroviruses and other DNA-based parasites by deaminating cytosines in single-stranded DNA during reverse transcription. It is part of the intrinsic antiviral restriction factor family.
How may the rs8177832 variant relate to Long COVID or ME/CFS?
APOBEC3G restricts viral DNA intermediates and shapes the mutational landscape of viruses. Its role in broader antiviral innate immunity may affect susceptibility to SARS-CoV-2 sequelae through modulation of viral diversity and clearance.
Can a consumer DNA test detect the rs8177832 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs8177832 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for APOBEC3G and its variants. This is not an exhaustive literature review.
- [1]PMID: 25056482
- [2]Nature
- [3]Cell Host & Microbe