rs429358
Variant in the APOE gene (Apolipoprotein E)
rs429358 is a single nucleotide polymorphism (SNP) in the APOE gene, involved in lipoprotein clearance / neuroinflammation / AD risk. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs429358 variant?
rs429358 is a SNP (single nucleotide polymorphism) in the APOE (Apolipoprotein E) gene. It belongs to the Metabolic category and is part of the Neurological & Cognitive Function biological cluster. APOE encodes apolipoprotein E, which mediates lipoprotein clearance and brain cholesterol transport; the APOE ε4 allele is the strongest genetic risk factor for Alzheimer's disease.
Biological role and pathway
This variant sits within the APOE gene, which is involved in the lipoprotein clearance / neuroinflammation / AD risk pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs429358 and Long COVID / ME-CFS research
APOE ε4 is associated with increased risk of severe COVID-19 and potentially Long COVID; it impairs neuroinflammation resolution and lipid transport in the brain, potentially contributing to Long COVID cognitive symptoms.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: APOE
rs429358 is one of 2 known variants in the APOE gene. To understand the full biological context of this variant, explore the parent gene page.
View APOE gene page →Conditions studied in relation to rs429358
Research into APOE variants including rs429358 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include APOE and the rs429358 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the APOE gene
The following variants in APOE are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs429358 variant in the APOE gene?
rs429358 is a single nucleotide polymorphism (SNP) located in the APOE (Apolipoprotein E) gene, which is involved in lipoprotein clearance / neuroinflammation / AD risk. APOE encodes apolipoprotein E, which mediates lipoprotein clearance and brain cholesterol transport; the APOE ε4 allele is the strongest genetic risk factor for Alzheimer's disease.
How may the rs429358 variant relate to Long COVID or ME/CFS?
APOE ε4 is associated with increased risk of severe COVID-19 and potentially Long COVID; it impairs neuroinflammation resolution and lipid transport in the brain, potentially contributing to Long COVID cognitive symptoms.
Can a consumer DNA test detect the rs429358 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs429358 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for APOE and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]NEJM