rs429358

What is the rs429358 variant?

rs429358 is a SNP (single nucleotide polymorphism) in the APOE (Apolipoprotein E (E4 isoform context)) gene. It belongs to the Lipid Metabolism category and is part of the Lipid Metabolism biological cluster. The APOE e4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease and also influences cardiovascular and inflammatory biology.

Biological role and pathway

This variant sits within the APOE gene, which is involved in the lipid transport and neurological function pathway. Genes within the Lipid Metabolism cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: APOE

rs429358 is one of 2 known variants in the APOE gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs429358

Research into APOE variants including rs429358 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include APOE and the rs429358 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the APOE gene

The following variants in APOE are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions