rs1959932
Variant in the ARC gene (Activity Regulated Cytoskeleton Associated Protein)
rs1959932 is a single nucleotide polymorphism (SNP) in the ARC gene, involved in synaptic plasticity / long-term memory. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1959932 variant?
rs1959932 is a SNP (single nucleotide polymorphism) in the ARC (Activity Regulated Cytoskeleton Associated Protein) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. ARC encodes activity-regulated cytoskeleton-associated protein, an immediate-early gene critical for long-term memory consolidation and synaptic plasticity.
Biological role and pathway
This variant sits within the ARC gene, which is involved in the synaptic plasticity / long-term memory pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1959932 and Long COVID / ME-CFS research
ARC expression is required for long-term memory; impaired ARC signaling may contribute to memory consolidation deficits and brain fog in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ARC
rs1959932 is one of 1 known variant in the ARC gene. To understand the full biological context of this variant, explore the parent gene page.
View ARC gene page →Conditions studied in relation to rs1959932
Research into ARC variants including rs1959932 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ARC and the rs1959932 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1959932 variant in the ARC gene?
rs1959932 is a single nucleotide polymorphism (SNP) located in the ARC (Activity Regulated Cytoskeleton Associated Protein) gene, which is involved in synaptic plasticity / long-term memory. ARC encodes activity-regulated cytoskeleton-associated protein, an immediate-early gene critical for long-term memory consolidation and synaptic plasticity.
How may the rs1959932 variant relate to Long COVID or ME/CFS?
ARC expression is required for long-term memory; impaired ARC signaling may contribute to memory consolidation deficits and brain fog in Long COVID.
Can a consumer DNA test detect the rs1959932 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1959932 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ARC and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Cell