rs2781659
Variant in the ARG1 gene (Arginase 1)
rs2781659 is a single nucleotide polymorphism (SNP) in the ARG1 gene, involved in arginine metabolism / M2 macrophage. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2781659 variant?
rs2781659 is a SNP (single nucleotide polymorphism) in the ARG1 (Arginase 1) gene. It belongs to the Metabolic category and is part of the Immune System & Inflammation biological cluster. ARG1 encodes arginase 1, an enzyme expressed in M2 macrophages and the liver that converts arginine to ornithine and urea, competing with NOS2 for arginine.
Biological role and pathway
This variant sits within the ARG1 gene, which is involved in the arginine metabolism / M2 macrophage pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2781659 and Long COVID / ME-CFS research
ARG1 activity in macrophages affects the balance between NO-mediated killing and tissue repair; variants may influence macrophage polarization and inflammatory resolution in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ARG1
rs2781659 is one of 2 known variants in the ARG1 gene. To understand the full biological context of this variant, explore the parent gene page.
View ARG1 gene page →Conditions studied in relation to rs2781659
Research into ARG1 variants including rs2781659 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ARG1 and the rs2781659 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ARG1 gene
The following variants in ARG1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2781659 variant in the ARG1 gene?
rs2781659 is a single nucleotide polymorphism (SNP) located in the ARG1 (Arginase 1) gene, which is involved in arginine metabolism / M2 macrophage. ARG1 encodes arginase 1, an enzyme expressed in M2 macrophages and the liver that converts arginine to ornithine and urea, competing with NOS2 for arginine.
How may the rs2781659 variant relate to Long COVID or ME/CFS?
ARG1 activity in macrophages affects the balance between NO-mediated killing and tissue repair; variants may influence macrophage polarization and inflammatory resolution in Long COVID.
Can a consumer DNA test detect the rs2781659 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2781659 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ARG1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Journal of Immunology