rs2228099
Variant in the ARNT gene (Aryl Hydrocarbon Receptor Nuclear Translocator)
rs2228099 is a single nucleotide polymorphism (SNP) in the ARNT gene, involved in xenobiotic sensing. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2228099 variant?
rs2228099 is a SNP (single nucleotide polymorphism) in the ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) gene. It belongs to the Metabolism category and is part of the Gut-Brain Axis biological cluster. ARNT (HIF-1β) dimerizes with both AHR and HIF-1α to drive transcriptional programs for xenobiotic metabolism and hypoxia adaptation respectively. It is a convergence point for two major stress-sensing pathways.
Biological role and pathway
This variant sits within the ARNT gene, which is involved in the xenobiotic sensing pathway. Genes within the Gut-Brain Axis cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2228099 and Long COVID / ME-CFS research
ARNT links hypoxia sensing (via HIF-1α) and xenobiotic/tryptophan sensing (via AHR) in a single obligate partner. Variants affecting ARNT may dysregulate both cellular hypoxia responses and tryptophan catabolism pathways relevant to Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ARNT
rs2228099 is one of 2 known variants in the ARNT gene. To understand the full biological context of this variant, explore the parent gene page.
View ARNT gene page →Conditions studied in relation to rs2228099
Research into ARNT variants including rs2228099 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ARNT and the rs2228099 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ARNT gene
The following variants in ARNT are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2228099 variant in the ARNT gene?
rs2228099 is a single nucleotide polymorphism (SNP) located in the ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) gene, which is involved in xenobiotic sensing. ARNT (HIF-1β) dimerizes with both AHR and HIF-1α to drive transcriptional programs for xenobiotic metabolism and hypoxia adaptation respectively. It is a convergence point for two major stress-sensing pathways.
How may the rs2228099 variant relate to Long COVID or ME/CFS?
ARNT links hypoxia sensing (via HIF-1α) and xenobiotic/tryptophan sensing (via AHR) in a single obligate partner. Variants affecting ARNT may dysregulate both cellular hypoxia responses and tryptophan catabolism pathways relevant to Long COVID.
Can a consumer DNA test detect the rs2228099 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2228099 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ARNT and its variants. This is not an exhaustive literature review.
- [1]PMID: 31784727
- [2]Nature Chemical Biology
- [3]Science