rs10210302
Variant in the ATG16L1 gene (Autophagy Related 16 Like 1)
rs10210302 is a single nucleotide polymorphism (SNP) in the ATG16L1 gene, involved in autophagosome formation / intestinal homeostasis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs10210302 variant?
rs10210302 is a SNP (single nucleotide polymorphism) in the ATG16L1 (Autophagy Related 16 Like 1) gene. It belongs to the Autophagy category and is part of the Mitochondrial Energy Production & PEM biological cluster. ATG16L1 is a component of the ATG12-ATG5-ATG16L1 complex; rs2241880 T300A variant affects Paneth cell function and is a major Crohn's disease risk factor.
Biological role and pathway
This variant sits within the ATG16L1 gene, which is involved in the autophagosome formation / intestinal homeostasis pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs10210302 and Long COVID / ME-CFS research
ATG16L1 T300A increases caspase-3-mediated cleavage, impairing Paneth cell secretory function and gut autophagy; this common variant may affect gut homeostasis and microbiome dysbiosis in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ATG16L1
rs10210302 is one of 2 known variants in the ATG16L1 gene. To understand the full biological context of this variant, explore the parent gene page.
View ATG16L1 gene page →Conditions studied in relation to rs10210302
Research into ATG16L1 variants including rs10210302 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ATG16L1 and the rs10210302 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ATG16L1 gene
The following variants in ATG16L1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs10210302 variant in the ATG16L1 gene?
rs10210302 is a single nucleotide polymorphism (SNP) located in the ATG16L1 (Autophagy Related 16 Like 1) gene, which is involved in autophagosome formation / intestinal homeostasis. ATG16L1 is a component of the ATG12-ATG5-ATG16L1 complex; rs2241880 T300A variant affects Paneth cell function and is a major Crohn's disease risk factor.
How may the rs10210302 variant relate to Long COVID or ME/CFS?
ATG16L1 T300A increases caspase-3-mediated cleavage, impairing Paneth cell secretory function and gut autophagy; this common variant may affect gut homeostasis and microbiome dysbiosis in Long COVID.
Can a consumer DNA test detect the rs10210302 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs10210302 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ATG16L1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]NEJM