rs2245214
Variant in the ATG5 gene (Autophagy Related 5)
rs2245214 is a single nucleotide polymorphism (SNP) in the ATG5 gene, involved in autophagosome membrane elongation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2245214 variant?
rs2245214 is a SNP (single nucleotide polymorphism) in the ATG5 (Autophagy Related 5) gene. It belongs to the Autophagy category and is part of the Mitochondrial Energy Production & PEM biological cluster. ATG5 forms the ATG12-ATG5-ATG16L1 E3-like complex essential for autophagosome membrane elongation.
Biological role and pathway
This variant sits within the ATG5 gene, which is involved in the autophagosome membrane elongation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2245214 and Long COVID / ME-CFS research
ATG5-mediated autophagosome formation is essential for xenophagy (viral autophagy); variants may impair SARS-CoV-2 clearance and contribute to persistent viral reservoirs in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ATG5
rs2245214 is one of 2 known variants in the ATG5 gene. To understand the full biological context of this variant, explore the parent gene page.
View ATG5 gene page →Conditions studied in relation to rs2245214
Research into ATG5 variants including rs2245214 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ATG5 and the rs2245214 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ATG5 gene
The following variants in ATG5 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2245214 variant in the ATG5 gene?
rs2245214 is a single nucleotide polymorphism (SNP) located in the ATG5 (Autophagy Related 5) gene, which is involved in autophagosome membrane elongation. ATG5 forms the ATG12-ATG5-ATG16L1 E3-like complex essential for autophagosome membrane elongation.
How may the rs2245214 variant relate to Long COVID or ME/CFS?
ATG5-mediated autophagosome formation is essential for xenophagy (viral autophagy); variants may impair SARS-CoV-2 clearance and contribute to persistent viral reservoirs in Long COVID.
Can a consumer DNA test detect the rs2245214 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2245214 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ATG5 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Cell
- [3]Immunity