rs2372536

What is the rs2372536 variant?

rs2372536 is a SNP (single nucleotide polymorphism) in the ATIC (5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. ATIC encodes a bifunctional enzyme in the de novo purine synthesis pathway; its substrate AICA-riboside (AICAR) activates AMPK.

Biological role and pathway

This variant sits within the ATIC gene, which is involved in the de novo purine synthesis / AMPK activation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: ATIC

rs2372536 is one of 1 known variant in the ATIC gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2372536

Research into ATIC variants including rs2372536 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ATIC and the rs2372536 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions