rs227060
Variant in the ATM gene (ATM Serine/Threonine Kinase)
rs227060 is a single nucleotide polymorphism (SNP) in the ATM gene, involved in DNA damage response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs227060 variant?
rs227060 is a SNP (single nucleotide polymorphism) in the ATM (ATM Serine/Threonine Kinase) gene. It belongs to the Dna Repair category and is part of the DNA Repair biological cluster. ATM encodes a kinase that is the master activator of the DNA damage response, phosphorylating key proteins including H2AX and p53 upon DNA strand breaks.
Biological role and pathway
This variant sits within the ATM gene, which is involved in the DNA damage response pathway. Genes within the DNA Repair cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs227060 and Long COVID / ME-CFS research
ATM-mediated DNA damage signaling may be activated by oxidative stress in Long COVID and contribute to cellular senescence and inflammation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ATM
rs227060 is one of 2 known variants in the ATM gene. To understand the full biological context of this variant, explore the parent gene page.
View ATM gene page →Conditions studied in relation to rs227060
Research into ATM variants including rs227060 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ATM and the rs227060 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ATM gene
The following variants in ATM are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs227060 variant in the ATM gene?
rs227060 is a single nucleotide polymorphism (SNP) located in the ATM (ATM Serine/Threonine Kinase) gene, which is involved in DNA damage response. ATM encodes a kinase that is the master activator of the DNA damage response, phosphorylating key proteins including H2AX and p53 upon DNA strand breaks.
How may the rs227060 variant relate to Long COVID or ME/CFS?
ATM-mediated DNA damage signaling may be activated by oxidative stress in Long COVID and contribute to cellular senescence and inflammation.
Can a consumer DNA test detect the rs227060 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs227060 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ATM and its variants. This is not an exhaustive literature review.
- [1]PMID: 26014458
- [2]Nature Genetics
- [3]Journal of Clinical Investigation