rs62627274
Variant in the ATP1A3 gene (ATPase Na+/K+ Transporting Subunit Alpha 3)
rs62627274 is a single nucleotide polymorphism (SNP) in the ATP1A3 gene, involved in neuronal Na+/K+-ATPase / membrane potential. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs62627274 variant?
rs62627274 is a SNP (single nucleotide polymorphism) in the ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. ATP1A3 encodes the alpha-3 subunit of Na+/K+-ATPase, expressed in neurons and critical for maintaining membrane potential and sodium/potassium gradients.
Biological role and pathway
This variant sits within the ATP1A3 gene, which is involved in the neuronal Na+/K+-ATPase / membrane potential pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs62627274 and Long COVID / ME-CFS research
Na+/K+-ATPase dysfunction impairs neuronal membrane potential; mutations cause alternating hemiplegia of childhood, and variants may affect neurological function and energy homeostasis in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ATP1A3
rs62627274 is one of 1 known variant in the ATP1A3 gene. To understand the full biological context of this variant, explore the parent gene page.
View ATP1A3 gene page →Conditions studied in relation to rs62627274
Research into ATP1A3 variants including rs62627274 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ATP1A3 and the rs62627274 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs62627274 variant in the ATP1A3 gene?
rs62627274 is a single nucleotide polymorphism (SNP) located in the ATP1A3 (ATPase Na+/K+ Transporting Subunit Alpha 3) gene, which is involved in neuronal Na+/K+-ATPase / membrane potential. ATP1A3 encodes the alpha-3 subunit of Na+/K+-ATPase, expressed in neurons and critical for maintaining membrane potential and sodium/potassium gradients.
How may the rs62627274 variant relate to Long COVID or ME/CFS?
Na+/K+-ATPase dysfunction impairs neuronal membrane potential; mutations cause alternating hemiplegia of childhood, and variants may affect neurological function and energy homeostasis in Long COVID.
Can a consumer DNA test detect the rs62627274 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs62627274 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ATP1A3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]NEJM