rs2071776
Variant in the ATP5F1A gene (ATP Synthase F1 Subunit Alpha)
rs2071776 is a single nucleotide polymorphism (SNP) in the ATP5F1A gene, involved in oxidative phosphorylation / ATP synthesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2071776 variant?
rs2071776 is a SNP (single nucleotide polymorphism) in the ATP5F1A (ATP Synthase F1 Subunit Alpha) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. ATP5F1A encodes the alpha subunit of mitochondrial ATP synthase (complex V), which synthesizes ATP from ADP using the proton gradient.
Biological role and pathway
This variant sits within the ATP5F1A gene, which is involved in the oxidative phosphorylation / ATP synthesis pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2071776 and Long COVID / ME-CFS research
Complex V ATP synthesis is the final step of oxidative phosphorylation; variants may affect ATP production efficiency and contribute to energy deficits and fatigue in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ATP5F1A
rs2071776 is one of 1 known variant in the ATP5F1A gene. To understand the full biological context of this variant, explore the parent gene page.
View ATP5F1A gene page →Conditions studied in relation to rs2071776
Research into ATP5F1A variants including rs2071776 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ATP5F1A and the rs2071776 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ATP5F1A gene
The following variants in ATP5F1A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2071776 variant in the ATP5F1A gene?
rs2071776 is a single nucleotide polymorphism (SNP) located in the ATP5F1A (ATP Synthase F1 Subunit Alpha) gene, which is involved in oxidative phosphorylation / ATP synthesis. ATP5F1A encodes the alpha subunit of mitochondrial ATP synthase (complex V), which synthesizes ATP from ADP using the proton gradient.
How may the rs2071776 variant relate to Long COVID or ME/CFS?
Complex V ATP synthesis is the final step of oxidative phosphorylation; variants may affect ATP production efficiency and contribute to energy deficits and fatigue in Long COVID.
Can a consumer DNA test detect the rs2071776 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2071776 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ATP5F1A and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Biochimica et Biophysica Acta