rs1058100

What is the rs1058100 variant?

rs1058100 is a SNP (single nucleotide polymorphism) in the B2M (Beta-2-Microglobulin) gene. It belongs to the Immune Presentation category and is part of the HLA & Immune Presentation biological cluster. B2M encodes beta-2-microglobulin, which forms a non-covalent complex with all MHC class I heavy chains, essential for their stability.

Biological role and pathway

This variant sits within the B2M gene, which is involved in the MHC class I assembly pathway. Genes within the HLA & Immune Presentation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: B2M

rs1058100 is one of 1 known variant in the B2M gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1058100

Research into B2M variants including rs1058100 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include B2M and the rs1058100 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions