rs145889
Variant in the BCL6 gene (BCL6 Transcription Repressor)
rs145889 is a single nucleotide polymorphism (SNP) in the BCL6 gene, involved in follicular helper T cell and germinal center B cell differentiation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs145889 variant?
rs145889 is a SNP (single nucleotide polymorphism) in the BCL6 (BCL6 Transcription Repressor) gene. It belongs to the Lymphocyte category and is part of the Lymphocyte Biology biological cluster. BCL6 encodes a transcriptional repressor that is the master regulator of germinal center B cells and T follicular helper cells.
Biological role and pathway
This variant sits within the BCL6 gene, which is involved in the follicular helper T cell and germinal center B cell differentiation pathway. Genes within the Lymphocyte Biology cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs145889 and Long COVID / ME-CFS research
BCL6-driven germinal center responses are central to durable antibody production; dysregulation may affect SARS-CoV-2 antibody quality in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: BCL6
rs145889 is one of 3 known variants in the BCL6 gene. To understand the full biological context of this variant, explore the parent gene page.
View BCL6 gene page →Conditions studied in relation to rs145889
Research into BCL6 variants including rs145889 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include BCL6 and the rs145889 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the BCL6 gene
The following variants in BCL6 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs145889 variant in the BCL6 gene?
rs145889 is a single nucleotide polymorphism (SNP) located in the BCL6 (BCL6 Transcription Repressor) gene, which is involved in follicular helper T cell and germinal center B cell differentiation. BCL6 encodes a transcriptional repressor that is the master regulator of germinal center B cells and T follicular helper cells.
How may the rs145889 variant relate to Long COVID or ME/CFS?
BCL6-driven germinal center responses are central to durable antibody production; dysregulation may affect SARS-CoV-2 antibody quality in Long COVID.
Can a consumer DNA test detect the rs145889 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs145889 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for BCL6 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation