rs4863546
Variant in the BDKRB1 gene (Bradykinin Receptor B1)
rs4863546 is a single nucleotide polymorphism (SNP) in the BDKRB1 gene, involved in kinin inflammatory signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4863546 variant?
rs4863546 is a SNP (single nucleotide polymorphism) in the BDKRB1 (Bradykinin Receptor B1) gene. It belongs to the Pain Sensory category and is part of the Pain & Sensory Processing biological cluster. BDKRB1 encodes bradykinin receptor B1, an inducible receptor upregulated in chronic inflammation that mediates sustained pain sensitization.
Biological role and pathway
This variant sits within the BDKRB1 gene, which is involved in the kinin inflammatory signaling pathway. Genes within the Pain & Sensory Processing cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4863546 and Long COVID / ME-CFS research
BDKRB1 upregulation in chronic inflammation may sustain bradykinin-driven pain sensitization and vascular permeability in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: BDKRB1
rs4863546 is one of 1 known variant in the BDKRB1 gene. To understand the full biological context of this variant, explore the parent gene page.
View BDKRB1 gene page →Conditions studied in relation to rs4863546
Research into BDKRB1 variants including rs4863546 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include BDKRB1 and the rs4863546 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the BDKRB1 gene
The following variants in BDKRB1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4863546 variant in the BDKRB1 gene?
rs4863546 is a single nucleotide polymorphism (SNP) located in the BDKRB1 (Bradykinin Receptor B1) gene, which is involved in kinin inflammatory signaling. BDKRB1 encodes bradykinin receptor B1, an inducible receptor upregulated in chronic inflammation that mediates sustained pain sensitization.
How may the rs4863546 variant relate to Long COVID or ME/CFS?
BDKRB1 upregulation in chronic inflammation may sustain bradykinin-driven pain sensitization and vascular permeability in Long COVID.
Can a consumer DNA test detect the rs4863546 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4863546 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for BDKRB1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32734001
- [2]Nature Genetics
- [3]Journal of Clinical Investigation