rs4900592
Variant in the BDKRB2 gene (Bradykinin Receptor B2)
rs4900592 is a single nucleotide polymorphism (SNP) in the BDKRB2 gene, involved in bradykinin signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4900592 variant?
rs4900592 is a SNP (single nucleotide polymorphism) in the BDKRB2 (Bradykinin Receptor B2) gene. It belongs to the Cardiovascular category and is part of the Coagulation & Vascular biological cluster. BDKRB2 is the constitutively expressed high-affinity receptor for bradykinin mediating vasodilation, vascular permeability, pain sensitization, and inflammation. ACE2 and ACE are key regulators of bradykinin degradation.
Biological role and pathway
This variant sits within the BDKRB2 gene, which is involved in the bradykinin signaling pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4900592 and Long COVID / ME-CFS research
A bradykinin storm (kinin excess from impaired ACE/ACE2 degradation) is proposed in COVID-19 pathogenesis. BDKRB2 variants affecting bradykinin signaling intensity may influence vascular inflammation, edema, hypotension, and POTS-like symptoms in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: BDKRB2
rs4900592 is one of 3 known variants in the BDKRB2 gene. To understand the full biological context of this variant, explore the parent gene page.
View BDKRB2 gene page →Conditions studied in relation to rs4900592
Research into BDKRB2 variants including rs4900592 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include BDKRB2 and the rs4900592 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the BDKRB2 gene
The following variants in BDKRB2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4900592 variant in the BDKRB2 gene?
rs4900592 is a single nucleotide polymorphism (SNP) located in the BDKRB2 (Bradykinin Receptor B2) gene, which is involved in bradykinin signaling. BDKRB2 is the constitutively expressed high-affinity receptor for bradykinin mediating vasodilation, vascular permeability, pain sensitization, and inflammation. ACE2 and ACE are key regulators of bradykinin degradation.
How may the rs4900592 variant relate to Long COVID or ME/CFS?
A bradykinin storm (kinin excess from impaired ACE/ACE2 degradation) is proposed in COVID-19 pathogenesis. BDKRB2 variants affecting bradykinin signaling intensity may influence vascular inflammation, edema, hypotension, and POTS-like symptoms in Long COVID.
Can a consumer DNA test detect the rs4900592 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4900592 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for BDKRB2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32826326
- [2]Science
- [3]Hypertension