rs2335761
Variant in the BECN1 gene (Beclin 1)
rs2335761 is a single nucleotide polymorphism (SNP) in the BECN1 gene, involved in autophagy initiation / PI3K complex. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2335761 variant?
rs2335761 is a SNP (single nucleotide polymorphism) in the BECN1 (Beclin 1) gene. It belongs to the Autophagy category and is part of the Mitochondrial Energy Production & PEM biological cluster. BECN1 encodes Beclin-1, which forms the Class III PI3K complex to initiate autophagosome formation.
Biological role and pathway
This variant sits within the BECN1 gene, which is involved in the autophagy initiation / PI3K complex pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2335761 and Long COVID / ME-CFS research
Beclin-1-mediated autophagy is important for viral clearance and mitochondrial quality control; variants may affect SARS-CoV-2 clearance efficiency and Long COVID viral persistence.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: BECN1
rs2335761 is one of 1 known variant in the BECN1 gene. To understand the full biological context of this variant, explore the parent gene page.
View BECN1 gene page →Conditions studied in relation to rs2335761
Research into BECN1 variants including rs2335761 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include BECN1 and the rs2335761 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the BECN1 gene
The following variants in BECN1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2335761 variant in the BECN1 gene?
rs2335761 is a single nucleotide polymorphism (SNP) located in the BECN1 (Beclin 1) gene, which is involved in autophagy initiation / PI3K complex. BECN1 encodes Beclin-1, which forms the Class III PI3K complex to initiate autophagosome formation.
How may the rs2335761 variant relate to Long COVID or ME/CFS?
Beclin-1-mediated autophagy is important for viral clearance and mitochondrial quality control; variants may affect SARS-CoV-2 clearance efficiency and Long COVID viral persistence.
Can a consumer DNA test detect the rs2335761 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2335761 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for BECN1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature
- [3]Cell