rs3733890

What is the rs3733890 variant?

rs3733890 is a SNP (single nucleotide polymorphism) in the BHMT (Betaine-Homocysteine S-Methyltransferase) gene. It belongs to the Methylation category and is part of the Methylation & Neurotransmitters biological cluster. BHMT encodes an enzyme that remethylates homocysteine using betaine as a methyl donor, providing an alternative methylation pathway.

Biological role and pathway

This variant sits within the BHMT gene, which is involved in the one-carbon metabolism pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: BHMT

rs3733890 is one of 1 known variant in the BHMT gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3733890

Research into BHMT variants including rs3733890 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include BHMT and the rs3733890 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions